Sickle Cell Dna Rna Mutation Worksheet

Sickle cell anemia is a genetic disease that affects hemoglobin the oxygen transport molecule in the blood.

Sickle cell dna rna mutation worksheet. Insertion one or more base pairs is added to a sequence. Sickle cell at the molecular level. G to c or a to g c g t c 2. The mutation causes these red blood cells to become stiff sickle shaped when they release their oxygen.

It is an inherited disease that is passed from parents to their children but parents can be carriers of the gene and not have any symptoms. Cgatgg cgaatgg gctacc gcttacc 3. The disease gets its name from to the shape of the red blood cells under certain conditions. If both parents are carriers their children have a 25 chance of having sickle cell anemia.

Sickle cell anemia is the result of a type of mutation in the gene that codes for part of the. In this activity students use a codon chart to compare the dna sequence of hba normal hemoglobin to hbs the hemoglobin found in blood of sickle cell patients. The dna differs in a single base where the codon for normal hemoglobin codes for glutamine and the mutant form codes for valine. In sickle cell anemia there is a mutation in the gene that encodes the beta chain of hemoglobin.

After reading sickle cell anemia and genetics background information answer the following questions. Sickle cell anemia is a genetic disease that affects hemoglobin the oxygen transport molecule in the blood. Substitution one base pairs is replaced by another.